Peritoneal Tumour Service Patient Day Christie 21st September
Peritoneal Tumour Service Patient Day Christie 21st September 2016 Research Professor Andrew G Renehan PhD FRCS FRCS(GenSurg) Colorectal & Peritoneal Oncology Centre, The Christie NHS Foundation Trust; Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, University of Manchester; Manchester Academic Health Science Centre Research framework 1. Pseudomyxoma peritonei (PMP) Appendiceal tumours 2. Appendiceal cancers 3. Peritoneal metastases from colorectal cancer Complications & mortality: cyto +HIPEC for PMP
No. of pts Complications (%) Mortality (%) Washington 501 40 2 Amsterdam 103 54
3 (4) 1 (0.4) 1 (1) 10.4% 17.6% UK & Ire. Peritoneal Tumour Services Reference treatment centres (appendiceal & PMCR) Hampshire Hospitals NHS FT The Christie NHS FT Other treatment centres (PMCR only) Mater Misericordiae University Hospital, Dublin Ninewells Hospital and Medical School, Dundee
Good Hope Hospital, Birmingham 6 Study Aim To develop a robust and reproducible framework in which to undertake a phase III trial in patients with PMCR suitable for CRS with or without HIPEC IDEAL Framework As CRS with HIPEC is a complex multicomponent component intervention, we propose to address this agenda using the principles of the IDEAL framework Idea Development Exploration Assessment
Long-term Study PMP: laboratory research Andrew Renehan Darren Roberts Peter Stern PMP: laboratory research Bowel cancer >50% Tumour PMP < 5% Tumour PMP cells Mucin
0.14 0.22 0.37 0.61 1.0 Future studies 1. Cell line high-through drug screens in PMP 2. Determine key driver genes in PMP 3. Characterise colorectal peritoneal metastases cancer with
Summary 1. Prospective outcome analyses 2. Trials (multi-step process) 3. Laboratory research Acknowledgements The Christie Colorectal & Peritoneal Oncology team Halstead ODwyer Butler Wilson Brown Selvasekar Fulford Tyrell Aziz Secretaries Minicozzi MDT coordinators Deshpande Kochhar
Mullin Saunders Braun Mullamitha Anaesthetists Theatre staff Perfusionists CCU staff Ward staff Chakrabarty Bowel Disease Research Foundation Christie data team Morrison Punnett Crichton Fernandez de-Silva
University of Manchester Emsley (statistics & methodology) Science laboratory Stern Roberts Brognard The patients
Members as at Feb 07: Greensols Pty. Ltd. (Prof. Chris Cuff) www.greensols.com.au TecEco Pty. Ltd. (John Harrison) www.tececo.com The name Gaia Engineering is a tribute to James Lovelock who got us all thinking that "We can't solve problems by using...
Assumptions of the Psychodynamic Approach. ... Preconscious: what we could be conscious of if we turned our attention. Unconscious: inaccessible . We do not have one unified personality, but 3 different parts. They pull us in different directions.
"It was James Gatz who had been loafing along the beach that afternoon …but it was already Jay Gatsby who borrowed a row boat…" It is as if Gatsby is rechristening himself Symbolises his desire to forget his lower class...
Hazardous Materials Oxygen Cylinders 7 cylinders in luggage bay had minimal fire damage 11 cylinders in passenger compartment had extensive fire damage Cylinder Design Cylinder contains large quantities of oxygen compressed to 2,015 psig Valve assembly pressure relief device (burst...
whole supply chain. Drives sustainability, consistency and standardisation of employment & skills requirements . across all . Highways England projects (…programme level standards and monitoring) Applicable to projects of . all sizes and types. Economies of scale can be achieved;...
Take 5 Minutes to write & Answer this Question Tell what is meant by a spontaneous reaction and then give ONE factor that cause a reaction to be spontaneous using --- G = H - TS Time to Start Class!...
Preliminary Project Execution Plan. Risk Management Plan . Risk Register. Comply with the One-for-One Building Space Replacement (only for projects with civil facility scope) Document High Performance & Sustainable Building and Sustainable Environmental Stewardship (only for projects with civil facility...
PI-SAGE-ENTReporting Instructionsfor AGR and SAGE schools. Contents. Click a topic below to proceed to that sectionor continue through the presentation. Overview. PI-SAGE-ENT Form (includes AGR schools) SAGE Flexibility (not applicable to AGR schools) Author: Jeff Pertl
Ready to download the document? Go ahead and hit continue!