Structures Reveal New Target for Malaria Vaccine Scientific
Structures Reveal New Target for Malaria Vaccine
Researchers isolated human-derived antibodies that
protect against malaria, and protein-structure
studies revealed the antibodies' site of attack.
Significance and Impact
The discovery paves the way for the development of
a more effective and practical human vaccine for
malaria, a disease responsible for half a million
deaths worldwide each year.
Interaction details between antibody
CIS43 (multicolored sticks, semitransparent surface) and peptide 21
Antibody CIS43 was isolated from a human volunteer who was given an experimental vaccine made from whole, weakened malaria parasites.
CIS43 (and other, similar antibodies) were co-crystallized with protein fragments
(peptides) from the surface of the malaria parasite.
The structures provided insights into why CIS43 binds more strongly to one
fragment (peptide 21), making it a promising target for vaccines.
Publication about this research: N.K. Kisalu et al., Nat. Med. 24, 408 (2018). Work was performed at Lawrence Berkeley National Laboratory, ALS
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