Structures Reveal New Target for Malaria Vaccine Scientific

Structures Reveal New Target for Malaria Vaccine Scientific

Structures Reveal New Target for Malaria Vaccine
Scientific Achievement
Researchers isolated human-derived antibodies that
protect against malaria, and protein-structure
studies revealed the antibodies' site of attack.

Diamondoids

Cu
S

Significance and Impact
The discovery paves the way for the development of
a more effective and practical human vaccine for
malaria, a disease responsible for half a million
deaths worldwide each year.

Research Details

Interaction details between antibody
CIS43 (multicolored sticks, semitransparent surface) and peptide 21
(purple sticks).

Antibody CIS43 was isolated from a human volunteer who was given an experimental vaccine made from whole, weakened malaria parasites.
CIS43 (and other, similar antibodies) were co-crystallized with protein fragments
(peptides) from the surface of the malaria parasite.
The structures provided insights into why CIS43 binds more strongly to one
fragment (peptide 21), making it a promising target for vaccines.
Publication about this research: N.K. Kisalu et al., Nat. Med. 24, 408 (2018). Work was performed at Lawrence Berkeley National Laboratory, ALS
Beamlines 5.0.1 and 5.0.2. Operation of the ALS is supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences program.

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