Kuby's Immunology \chapter 12 - University of Windsor

Kuby's Immunology \chapter 12 - University of Windsor

T cell Maturation, Activation & Differentation Hugh B. Fackrell 02/10/20 1 T cell Maturation, Activation & Differentation Assigned Reading Content Outline Performance Ojectives

Key terms Key Concepts Short Answer Questions 02/10/20 2 Assigned Reading Chapter: 12 pp 285-310 Janis Kubys Immunology 3rd Ed

02/10/20 3 Content Outline T Cell Maturation T helper Cell Activation

T Cell Differentiation Peripheral gamma delta T cells 02/10/20 4 T Cell Maturation Pre T cell receptor

T cell development pathways Thymic Selection of T cells positive selection negative selection T helper Cell Activation 02/10/20

TCR coupled signaling pathways Co-stimulatory signal

Antagonists & Agonists Clonal Expansion Clonal Anergy Superantigens 5 T Cell Differentiation Effector & memory cells Co-stimulatory differences 02/10/20

6 Peripherial T cells Distribution of cells Ligands recognized Functions 02/10/20 7 Performance Objectives

02/10/20 8 Key Terms accessory molecules, antigen processing, associatve recogonition model, independent recognition model, cell adhesion molecules, subtractive hybrization

02/10/20 9 Key Concepts Outline antigen processing and presentation to TCR Describe the molecular pathways for T cell activation Describe positive and negative selection Discuss the role of accessory molecules in T cell antigen recognition

02/10/20 10 Short Answer Questions 02/10/20 11 T cell proliferation and differentiation lead to important immunological functions. What are they? Briefly discuss the molecular events,

collected called T-Cell activation, that lead to biologic function. What is the importance of diacylglycerol and IP3 in T-cell activation? What transcription factors are involved in T cell activation? 02/10/20 12 DONE!!!

02/10/20 13

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