Chapter 36 Nutrition and Colon Cancer

Chapter 36 Nutrition and Colon Cancer

Chapter 36 Nutrition and Colon Cancer FIGURE 36.1: (A) Aberrant crypt foci (ACF) and (B) mucin-depleted foci (MDF) in rat colon. ACF are visualized by staining whole mounts of colon with methylene blue. MDF are ACF that show no mucin staining using high-iron diamine alcian blue. Normal crypts stain black. Copyright 2016 Elsevier Inc. All rights

reserved. FIGURE 36.2: An overview of the pathway of chemical carcinogenesis. Indirect carcinogens can be detoxified through phase I and phase II metabolism, although for a few compounds, phase II metabolism can lead to carcinogen activation (dottedline). However, some indirect carcinogens are activated by phase I metabolism, leading to mutations in DNA through formation of DNA adducts. DNA repair mechanisms can remove the adducts. If mutation is extensive, this can result in cell death through apoptosis. However, if the DNA is not repaired correctly, and DNA replication occurs, this can lead to a permanent mutation,forming an initiated cell. Additional mutations or promoters of cell proliferation can lead to

hyperproliferation and potentially a tumor. Adapted from G.A. Belitsky, M.G. Yakubovskaya, Genetic polymorphism and variability of chemical carcinogenesis, Biokhimiya 73 (2008) 675689, http://www.protein.bio.msu.ru/biokhimiya/contents/v73/ full/73050675.html. Copyright 2016 Elsevier Inc. All rights reserved. FIGURE 36.3 An overview of phase I and phase II metabolism.Carcinogens can undergo oxidation reactions that allow

conjugation with glutathione by GSTs Alternatively, carcinogens can undergo hydrolysis or reduction reactions, and subsequently be sulfated by SULTs, acetylated by N-acetyltransferases, or glucuronidated by UGTs. The result is a more hydrophilic compound that can be excreted in the bile or urine. Adapted from https ://commons.wikimedia.org/wiki/File Xenobiotic_metabolism.png Copyright 2016 Elsevier Inc. All rights reserved.

FIGURE 36.4: Structure of two foodborne HAAs, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) and 2-amino3,4-dimethylimidazo[4,5-f] quinolone (MeIQ) and their DNA adducts N-(deoxyguanosin-8-yl)PhIP (dG-C8PhIP) and N(deoxyguanosin-8-yl)MeIQ (dG-C8MeIQ). Copyright 2016 Elsevier Inc. All rights reserved.

Recently Viewed Presentations

  • Talking Mats App for AHPs - NHS Education for Scotland

    Talking Mats App for AHPs - NHS Education for Scotland

    Dr Joan Murphy. Talking Mats Ltd. Stirling. copyright Talking Mats Ltd 2015. Background. Helps people participate in conversations and express their views. Evidence based resource WHO-ICF. Previously low-tech. Now - web browsers, iPad and Android tablets and Smart Boards.
  • Blended learning (traditional versus and online courses) Alex

    Blended learning (traditional versus and online courses) Alex

    eTextbooks - Inkling. Conclusions. Blended learning is a (proven) better alternative than traditional or fully online courses. With recent advances in technology, there is a rich offering of tools that can help instructors and students in blended learning.
  • Delegation Example in a Health Care Setting Students

    Delegation Example in a Health Care Setting Students

    Delegation and choosing stakeholder require critical factors. Effective delegation improve efficiency and quality care. Delegation is complex, but necessary in healthcare. Conclusion. Delegation is an important and powerful tool in a hospital setting to assign responsibilities and authority from the...
  • Diapositiva 1 - WordPress.com

    Diapositiva 1 - WordPress.com

    PLATÓN Y LA FILOSOFÍA ANTERIOR INFLUENCIAS EN LA DOCTRINA PLATÓNICA Inmortalidad del alma humana. Importancia de las matemáticas (los entes matemáticos son Ideas para Platón).
  • Math & Science: Gateways to STEM Degrees and

    Math & Science: Gateways to STEM Degrees and

    HVAC, Industrial/Residential Electricity , Mechanical Maintenance , Precision Machining Technology , Welding . Career Studies Certificates. 21 Program Majors. John Tyler's Other Programs Of Study. Transfer Programs (AS or AA degrees) Business. General Studies.
  • Venerable Edel Quinn September 14, 1907 - May 12, 1944

    Venerable Edel Quinn September 14, 1907 - May 12, 1944

    The six praesidia within walking distance of St. Peter Claver Church participated in the first Acies. (Some of the members walked twelve miles each way to attend.) Seven priest spiritual directors attended and are seen in the photo with Edel...
  • Secured Transactions Assignment 4 - OU Law

    Secured Transactions Assignment 4 - OU Law

    The Secured Party forecloses and the court orders a sale. Credit Bidding. Sheriff. $100K. Collateral. If the secured party is the Buyer, the money would go in a circle. So the law excuses both payments. ... Secured Transactions Assignment 4...
  • Incorporating Social Science into NOAA's Tsunami Program

    Incorporating Social Science into NOAA's Tsunami Program

    Incorporating Social Science into NOAA's Tsunami Program. National Tsunami Hazard Mitigation Program. San Diego, CA. February 8, 2012. Award: NA10NWS4670015. Colleen Scott, Winn Ketchum, Kasie Richards, Emma Apatu (ETSU) Victoria Johnson and Stuart Frazer (GNS Science) Courtney Farnham(UC) Chris Gregg...